There are some short and long term complications linked with hyaluronate injections for knee pain, however, they are rare. The most common side effect is a temporary flare–up of symptoms for a couple of days.

Your doctor can provide more information about sodium hyaluronate.

There may be other drugs that can interact with sodium hyaluronate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction:
hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

• > severe pain or swelling around the knee after the injection
• > fast heart rate, sweating, chills or shaking

Less serious side effects may include:

• > warmth, pain, stiffness, swelling, or puffiness where the medicine was injected;
• > ausea, stomach pain;
• > headache;
• > back pain;
• > numbness or tingly feeling;
• > cold symptoms such as stuffy nose, sneezing, sore throat;
• > tired feeling; or
• > itching or skin irritation around the knee.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For at least 48 hours after your injection, avoid jogging, strenuous activity, or high-impact sports such as soccer or tennis. Also avoid weight-bearing activity or standing for longer than 1 hour at a time. Ask your doctor how long to wait before you resume these activities.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Sodium hyaluronate is injected directly into your knee joint. A healthcare provider will give you this injection. To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

You should not receive sodium hyaluronate if you are allergic to it, or if you have an infection in your knee or in the skin around your knee. To make sure you can safely receive sodium hyaluronate, tell your doctor if you have:

• blood clots or circulation problems in your legs; or
• an allergy to birds, feathers, or egg products.

It is not known whether sodium hyaluronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether sodium hyaluronate passes into breast milk or if it could harm a nursing baby. Do not use this medical device/product without telling your doctor if you are breast-feeding a baby.

Sodium hyaluronate is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.
Sodium hyaluronate is used to treat knee pain caused by osteoarthritis.
Sodium hyaluronate is usually given after other arthritis medications have been tried without successful treatment of symptoms. Sodium hyaluronate may also be used for purposes not listed in this medication guide.